Description
Esculap (Tadalafil 20mg. | 20 tabs.)
The Balkan Esculap (Tadalafil) is a selective, efficient and reversible inhibitor of type 5 phosphodiesterase (PDE5), cyclic guanosine monophosphate (cGMP). When sexual arousal causes local release of nitric oxide, inhibition of tadalafil PDE5 leads to an increase in cGMP levels in the cavernous body of the penis.
The consequence is the relaxation of the smooth muscles of the arteries and the flow of blood into the tissues of the penis, which causes an erection. Tadalafil does not work in the absence of sexual stimulation.
In vitro studies have shown that tadalafil is a selective PDE5 inhibitor. PDE5 is an enzyme found in the smooth muscles of the corpus cavernosum, the smooth muscles of internal organ vessels, skeletal muscles, platelets, kidneys, lungs and cerebellum.
The action of the Balkan Esculap (Tadalafil) on PDE5 is more active than other phosphodiesterases. Tadalafil is 10,000 times more potent for PDE5 than for PDE1, PDE2 and PDE4, which are in the heart, brain, blood vessels, liver and other organs. Tadalafil 10,000 times more actively blocks PDE5 than PDE3 – an enzyme found in the heart and blood vessels.
This selectivity for PDE5 compared to FDHD is important because FDEZ is an enzyme involved in the contraction of the heart muscle. In addition, tadalafil is approximately 700 times more active than PDE5 than PDE6, which is found in the retina and is responsible for photo transmission. Tadalafil also has a 10,000-fold stronger effect on PDE5 than its effect on PDE7-PDE10.
Tadalafil improves erection and the possibility of successful sex. The medicine is valid for 36 hours. The effect is still 16 minutes after drug administration in the presence of sexual arousal.
Tadalafil in healthy individuals did not cause significant changes in systolic and diastolic blood pressure compared to placebo in the posterior lying position (maximum mean decrease of 1 6/0, 8 mm HgV, respectively) and standing (mean mean decrease in 0, 2/4 and 6 mm Hg, respectively).
Tadalafil does not cause a significant change in heart rate.
Tadalafil does not cause changes in color recognition (blue / green), which is explained by the low affinity for PDEB. In addition, there is no effect of tadalafil on visual acuity, electroretinogram, intraocular pressure, and pupil size.
In the male tadalafil study at a daily dose of 10 mg, there was no clinically significant effect of the drug on sperm count, sperm motility and sperm count and concentration.
Balkan Esculap Pharmacokinetics (Tadalafil): After taking tadalafil in, tadalafil is rapidly absorbed. The maximum mean plasma concentration (C max) is reached on average 2 hours after ingestion.
The rate and extent of absorption of tadalafil do not depend on food intake, so that tadalafil can be given regardless of food intake. Receiving time (morning or evening) had no clinically significant effect on the rate and extent of absorption.
Indications: Tadalafil is indicated for erectile dysfunction.
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